Neurexan - Your Way to Calm

The NEURIM study shows that the Heel medicine Neurexan® reduces the stress response in stress-relevant brain areas.¹ Results have now been published in a first article¹ in the Nature Publishing Group journal “Scientific Reports”.

The NEURIM study has been conducted at the universities of Magdeburg and Tübingen. It was led by a psychiatrist and researcher in the field of biomedical image analysis, Prof. Dr. Martin Walter, who is now at the at the university of Jena. He was supported by a team of colleagues from the universities of Tübingen and Magdeburg.

The study showed that Neurexan® (Nx4) reduced the brain’s response in the amygdala and other stress-relevant brain areas to negative emotional stimuli. This clinical trial used state of the art technology and has now been published in Scientific Reports, a peer-reviewed journal from the Nature Publishing Group.

The NEURIM Study

39 mildly to moderately stressed healthy volunteers received Neurexan® in a randomized, placebo-controlled, double-blind, two-period crossover study. Afterwards, their brain responses were evaluated amongst others with fMRI (functional magnetic resonance imaging), a method to assess whether an area of the brain is active or not, while the participants were either at rest or under emotional stress.

The amygdala, an important part of the limbic system and often called the stress center in the brain, is activated by stress. In return vigilance and anxiety in the brain increase, leading to an increased stress response in the body. Neuroimaging this stress response in the amygdala via the fMRI technology is in the focus of this publication.

Outcome Animations

These six NEURIM Trial Outcome Animations present comprehensively the complex results of this trial.

These concise videos provide insights into Neurexan® and its impact on emotions, attention, stress, and more.

Also, a short animation of the NEURIM study , its design, methods and results:

Download The Neurexan Detailed Brochure

The Neurexan Detailed Brochure has been updated with the results from the NEURIM study and the results from the Dimpfel study.

It discusses stress and its relation to nervous restlessness and sleep disturbances, Neurexan's ingredients and their suggested effect as well as pre-clinical and clinical evidence for efficacy and tolerability.

About Neurexan®

Neurexan® is an effective, fast acting multi-component, multi-target natural medication that provides relief from restlessness and sleep disorders. Neurexan has a very good safety profile, is non-addictive, non-sedative, does not cause daytime drowsiness or concentration deficits and is very well tolerated.

^{1Herrmann, L., Vicheva, P., Kasties, V. et al. fMRI Revealed Reduced Amygdala Activation after Nx4 in Mildly to Moderately Stressed Healthy Volunteers in a Randomized, Placebo-Controlled, Cross-Over Trial. Sci Rep 10, 3802 (2020).https://doi.org/10.1038/s41598-020-60392-w}